I submitted my resume and cover letter using the company's web based application form. I was called a few days later to schedule the first interview a week out. Since I already work for The Home Depot I was familiar with their standard two person interview process with one asking the questions and the other taking notes. Most of the questions are open ended and are best answered with a "story" where you relate how you identified and solved the problem .
After the standard questions it's your turn to ask questions and further qualify if this is a good fit for you.